Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | REN | P00797 | 5/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357804 | 0.86 | KLK5 (0.55) | KLK5L3MBTL1KMT2AREN | |
| SCHEMBL7359025 | 0.86 | KLK5 (0.55) | KLK5L3MBTL1KMT2AREN | |
| SCHEMBL7360172 | 0.85 | KLK5 (0.58) | KLK5L3MBTL1KMT2ARENPSEN1 | |
| SCHEMBL7325758 | 0.85 | KLK5 (0.58) | KLK5L3MBTL1KMT2ARENPSEN1 | |
| SCHEMBL10377216 | 0.85 | KLK5 (0.58) | KLK5L3MBTL1KMT2ARENPSEN1 | |
| SCHEMBL7326978 | 0.84 | KLK5 (0.55) | KLK5L3MBTL1REN | |
| SCHEMBL7362805 | 0.84 | KLK5 (0.55) | KLK5L3MBTL1REN | |
| SCHEMBL7332548 | 0.82 | KMT2A (0.53) | KLK5L3MBTL1MEN1KMT2APSEN1 | |
| SCHEMBL7330949 | 0.80 | KLK5 (0.58) | KLK5MEN1KMT2ARENPSEN1 | |
| SCHEMBL7323031 | 0.80 | KLK5 (0.58) | KLK5MEN1KMT2ARENPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415981-A4 | RETROVIRAL PROTEASE INHIBITORS | — | 1991-10-09 | — | — | EP | disclosed |
| EP-0415981-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0342541-A2 | Retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1989-11-23 | — | — | EP | disclosed |
| WO-1989010752-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |