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Sugi Predict / Compounds / SCHEMBL7365101

SCHEMBL7365101

SCHEMBL7365101

CC(c1cccc(Cl)c1)C(Nc1ccccc1C(=O)Nc1ccc(Cl)cn1)C1CCNCC1

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ F10 P00742 17/20 0.46
▸ NPC1 O15118 1/20 0.45
▸ ALOX15 P16050 1/20 0.45
▸ HTT P42858 1/20 0.45
▸ RAB9A P51151 1/20 0.45
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ TDP1 Q9NUW8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6714678 0.88 NPC1 (0.53) F10NPC1ALOX15HTTRAB9A
SCHEMBL6411338 0.85 NPC1 (0.53) F10NPC1ALOX15HTTRAB9A
Hydrochloric Acid SCHEMBL6710608 0.83 NPC1 (0.53) F10NPC1ALOX15HTTRAB9A
SCHEMBL7358930 0.79 F10 (0.52) F10NPC1ALOX15HTTRAB9A
SCHEMBL7365896 0.79 F10 (0.52) F10NPC1ALOX15HTTRAB9A
SCHEMBL6713141 0.79 F10 (0.50) F10NPC1ALOX15HTTRAB9A
SCHEMBL7357844 0.78 F10 (0.52) F10NPC1ALOX15HTTRAB9A
SCHEMBL6415440 0.78 F10 (0.49) F10NPC1ALOX15HTTRAB9A
SCHEMBL7358439 0.78 F10 (0.51) F10NPC1RAB9A
Hydrochloric Acid SCHEMBL7358233 0.78 F10 (0.49) F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140903-A1 AROMATIC AMIDES ELI LILLY AND COMPANY (US) 2001-10-10 — — EP disclosed
WO-2000039118-A1 AROMATIC AMIDES ELI LILLY AND COMPANY (US) 2000-07-06 — — WO disclosed
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