Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 11/20 | 0.80 |
| ▸ | PLG | P00747 | 7/20 | 0.69 |
| ▸ | PLAT | P00750 | 6/20 | 0.69 |
| ▸ | KLKB1 | P03952 | 6/20 | 0.69 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.69 |
| ▸ | F2 | P00734 | 5/20 | 0.69 |
| ▸ | THRB | P10828 | 1/20 | 0.67 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.65 |
| ▸ | KLK1 | P06870 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342729 | 0.93 | PLAU (0.83) | PLAUPLGPLATKLKB1PRSS1 | |
| SCHEMBL7344439 | 0.89 | PLAU (1.00) | PLAUPLGPLATKLKB1PRSS1 | |
| SCHEMBL7345163 | 0.83 | PLAU (1.00) | PLAUPLGPLATKLKB1PRSS1 | |
| Trifluoroacetic Acid SCHEMBL7853915 | 0.82 | PLAU (0.86) | PLAUPLGPLATKLKB1PRSS1 | |
| SCHEMBL7341931 | 0.82 | PLAU (1.00) | PLAUPLGPLATKLKB1PRSS1 | |
| SCHEMBL7344349 | 0.81 | PLAU (0.74) | PLAUPLGPLATKLKB1PRSS1 | |
| SCHEMBL19479048 | 0.80 | PRSS1 (0.60) | PLAUPLGPRSS1F2 | |
| SCHEMBL7337835 | 0.79 | PLAU (1.00) | PLAUPLGPLATKLKB1PRSS1 | |
| SCHEMBL7336652 | 0.79 | PLAU (0.70) | PLAUPLGPLATKLKB1PRSS1 | |
| SCHEMBL19479031 | 0.78 | PRMT1 (0.61) | PLAUPLGPRSS1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000018-A2 | UROKINASE INHIBITORS | Abbott Laboratories (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005096-A2 | UROKINASE INHIBITORS | ABBOTT LABORATORIES (US) | 1999-02-04 | — | — | WO | disclosed |