Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 11/20 | 0.74 |
| ▸ | PLG | P00747 | 6/20 | 0.67 |
| ▸ | PLAT | P00750 | 5/20 | 0.67 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.67 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.67 |
| ▸ | F2 | P00734 | 4/20 | 0.67 |
| ▸ | KLK1 | P06870 | 1/20 | 0.67 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.58 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | F10 | P00742 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449026 | 0.90 | NR1H4 (0.72) | PLAUNR1H4MEN1KMT2ASIRT2 | |
| SCHEMBL7344439 | 0.85 | PLAU (1.00) | PLAUPLGPLATKLKB1PRSS1 | |
| SCHEMBL7337835 | 0.85 | PLAU (1.00) | PLAUPLGPLATKLKB1PRSS1 | |
| SCHEMBL14132190 | 0.84 | F2 (0.66) | PLAUF2NR1H4SIRT2SIRT1 | |
| SCHEMBL11550139 | 0.83 | NR1H4 (0.81) | NR1H4MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7342729 | 0.83 | PLAU (0.83) | PLAUPLGPLATKLKB1PRSS1 | |
| SCHEMBL7344354 | 0.82 | NR1H4 (0.59) | PLAUNR1H4MEN1KMT2ASIRT2 | |
| SCHEMBL4324160 | 0.82 | PLAU (1.00) | PLAUPLGPLATKLKB1PRSS1 | |
| SCHEMBL7365142 | 0.81 | PLAU (0.80) | PLAUPLGPLATKLKB1PRSS1 | |
| Trifluoroacetic Acid SCHEMBL7853915 | 0.81 | PLAU (0.86) | PLAUPLGPLATKLKB1PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010049374-A1 | Urokinase inhibitors | STEELE ANDREW W (US) | 2001-12-06 | — | — | US | disclosed |
| US-6284796-B1 | NAPHTHAMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-09-04 | — | — | US | disclosed |
| US-6258822-B1 | ENZYME INHIBITORS OF NAPHTHALENE AMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-07-10 | — | — | US | disclosed |
| EP-1000018-A2 | UROKINASE INHIBITORS | Abbott Laboratories (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005096-A2 | UROKINASE INHIBITORS | ABBOTT LABORATORIES (US) | 1999-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010049374-A1 | Urokinase inhibitors | SERPINE1, PLAU, SERPINB1 | PLAU 2/4885PLG 10/4885PLAT 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.