Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 12/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 12/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 12/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 12/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 12/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 12/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5967172 | 0.93 | PSEN1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5967186 | 0.89 | TSHR (0.46) | TACR3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5967178 | 0.89 | TSHR (0.46) | TACR3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7369517 | 0.83 | REN (0.44) | TACR3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7392430 | 0.82 | CMA1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5967121 | 0.80 | REN (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5966997 | 0.79 | TSHR (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5967145 | 0.79 | TSHR (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7444671 | 0.79 | TSHR (0.36) | TACR3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7404787 | 0.76 | PSEN1 (0.37) | TACR3PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942924-A2 | METHODS AND COMPOUNDS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | Elan Pharmaceuticals, Inc. (US) | 1999-09-22 | — | — | EP | claimed |
| WO-1998022494-A9 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | — | 1998-08-20 | — | — | WO | claimed |
| WO-1998022494-A2 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | ELAN PHARMACEUTICALS, INC. (US) | 1998-05-28 | — | — | WO | claimed |