Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050133 | 0.85 | NPC1 (0.50) | CA12CA1CA2CA9LMNA | |
| Water SCHEMBL7364487 | 0.83 | NPC1 (0.48) | CA12CA1CA2CA9LMNA | |
| SCHEMBL1287539 | 0.81 | LMNA (0.52) | CA12CA1CA2CA9LMNA | |
| SCHEMBL348215 | 0.77 | LMNA (0.54) | CA12CA1CA2CA9LMNA | |
| SCHEMBL13607694 | 0.77 | LMNA (0.51) | CA12CA1CA2CA9LMNA | |
| SCHEMBL72493 | 0.76 | LMNA (0.53) | CA12CA1CA2CA9LMNA | |
| SCHEMBL6606644 | 0.76 | LMNA (0.53) | CA12CA1CA2CA9LMNA | |
| SCHEMBL73352 | 0.76 | LMNA (0.56) | CA12CA1CA2CA9LMNA | |
| SCHEMBL121110 | 0.76 | LMNA (0.53) | CA12CA1CA2CA9LMNA | |
| SCHEMBL6837760 | 0.76 | LMNA (0.47) | CA12CA1CA2CA9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 1999-03-17 | — | — | EP | disclosed |
| EP-0873331-A1 | BENZOFURAN CARBOXAMIDES AND SULPHONAMIDES | Darwin Discovery Limited (GB) | 1998-10-28 | — | — | EP | disclosed |
| WO-1997044337-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |
| WO-1997020833-A1 | BENZOFURAN CARBOXAMIDES AND SULPHONAMIDES | DARWIN DISCOVERY LIMITED (GB) | 1997-06-12 | — | — | WO | disclosed |