Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6369657 | 0.90 | SMN1; SMN2 (0.60) | PTGDR2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL2561771 | 0.87 | PTGDR2 (0.57) | PTGDR2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL29958222 | 0.86 | PTGDR2 (0.56) | PTGDR2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL15333027 | 0.84 | KDM4E (0.67) | PTGDR2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL15330029 | 0.84 | LMNA (0.56) | PTGDR2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL2562211 | 0.84 | PTGDR2 (0.54) | PTGDR2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL2109475 | 0.82 | PTGDR2 (0.66) | PTGDR2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL20249071 | 0.82 | PTGDR2 (0.51) | PTGDR2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL2560324 | 0.82 | PTGDR2 (0.57) | PTGDR2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL7294511 | 0.82 | PTGDR2 (0.61) | PTGDR2RAB9ANPC1NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378718-A | Cardiovascular activity, hypotensive | CEDONA PHARMACEUTICALS B.V. (NL) | 1995-01-03 | — | — | US | disclosed |
| WO-1992002503-A1 | NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES | CEDONA PHARMACEUTICALS BV (NL) | 1992-02-20 | — | — | WO | disclosed |