Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | YWHAB | P31946 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15332808 | 0.87 | PTGDR2 (0.59) | PTGDR2HSD17B10ALDH1A1HPGDHTT | |
| SCHEMBL2558935 | 0.85 | PTGDR2 (0.56) | PTGDR2HSD17B10ALDH1A1HPGDHTT | |
| SCHEMBL2560739 | 0.85 | MAPT (0.65) | PTGDR2HSD17B10ALDH1A1HPGDHTT | |
| SCHEMBL29950848 | 0.85 | KMT2A (0.62) | PTGDR2HSD17B10ALDH1A1HPGDHTT | |
| SCHEMBL2552236 | 0.85 | HPGD (0.67) | PTGDR2HSD17B10ALDH1A1HPGDHTT | |
| SCHEMBL29955221 | 0.84 | PTGDR2 (0.62) | PTGDR2HSD17B10ALDH1A1HPGDHTT | |
| SCHEMBL2555017 | 0.83 | MAPT (0.56) | PTGDR2HSD17B10ALDH1A1HPGDHTT | |
| SCHEMBL22588977 | 0.83 | PTGDR2 (0.55) | PTGDR2HSD17B10ALDH1A1HPGDHTT | |
| SCHEMBL2562334 | 0.82 | HPGD (0.57) | PTGDR2HSD17B10ALDH1A1HPGDHTT | |
| SCHEMBL2558036 | 0.81 | PTGDR2 (0.59) | PTGDR2HSD17B10ALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378718-A | Cardiovascular activity, hypotensive | CEDONA PHARMACEUTICALS B.V. (NL) | 1995-01-03 | — | — | US | disclosed |
| WO-1992002503-A1 | NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES | CEDONA PHARMACEUTICALS BV (NL) | 1992-02-20 | — | — | WO | disclosed |