Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
| ▸ | PDE5A | O76074 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8693757 | 0.93 | PDE5A (0.51) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7361880 | 0.92 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7364301 | 0.85 | HTT (0.47) | PDE4APDE5AHPGDHTTSMN1; SMN2 | |
| SCHEMBL7359586 | 0.85 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7364759 | 0.81 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL8306609 | 0.80 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7364065 | 0.80 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7365928 | 0.79 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7361643 | 0.77 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7359530 | 0.77 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |