Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 4/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | EDNRB | P24530 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365746 | 0.93 | PDE4A (0.56) | PDE5AALDH1A1GAAPDE4APDE4B | |
| SCHEMBL7359586 | 0.92 | PDE4A (0.57) | PDE5AALDH1A1GAAPDE4APDE4B | |
| SCHEMBL7364301 | 0.86 | HTT (0.47) | PDE5AALDH1A1GAAPDE4ACYP1A2 | |
| SCHEMBL7361880 | 0.85 | PDE4A (0.67) | PDE5AALDH1A1GAAPDE4APDE4B | |
| SCHEMBL7369761 | 0.82 | ALDH1A1 (0.70) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7368929 | 0.82 | TSHR (0.50) | ALDH1A1GAAPDE4APDE4BPDE4C | |
| SCHEMBL7364759 | 0.82 | PDE4A (0.52) | PDE5AALDH1A1GAAPDE4APDE4B | |
| SCHEMBL7363442 | 0.80 | PDE4A (0.71) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7366591 | 0.79 | ALDH1A1 (0.59) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7369583 | 0.79 | ALDH1A1 (0.56) | ALDH1A1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716954-A | ANTIINFLAMMATORY AGENT, ANTIHISTAMINES, IMMUNOSUPPRESSION,AUTOIMMUNE DISEASES | SYNTEX U.S.A. INC. (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |