Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.75 |
| ▸ | HDAC2 | Q92769 | 15/20 | 0.75 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.75 |
| ▸ | HDAC4 | P56524 | 12/20 | 0.75 |
| ▸ | HDAC7 | Q8WUI4 | 12/20 | 0.75 |
| ▸ | HDAC10 | Q969S8 | 12/20 | 0.75 |
| ▸ | HDAC11 | Q96DB2 | 12/20 | 0.75 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.75 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.75 |
| ▸ | HDAC9 | Q9UKV0 | 12/20 | 0.75 |
| ▸ | HDAC5 | Q9UQL6 | 12/20 | 0.75 |
| ▸ | MMP3 | P08254 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9782295 | 0.97 | HDAC1 (0.75) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| Lithium Ion SCHEMBL7372953 | 0.94 | HDAC1 (0.65) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL7368556 | 0.86 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL7394977 | 0.86 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL7515225 | 0.85 | HDAC3 (0.77) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL3381443 | 0.85 | HDAC3 (0.77) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL1007408 | 0.85 | HDAC3 (0.77) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL7374757 | 0.83 | HDAC1 (0.78) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL7739114 | 0.83 | HDAC1 (0.72) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL7738398 | 0.83 | HDAC1 (0.72) | HDAC1HDAC2HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020177594-A1 | Inhibitors of histone deacetylase | ABBOTT LABORATORIES | 2002-11-28 | — | — | US | disclosed |
| US-20020103192-A1 | Inhibitors of histone deacetylase | ABBOTT LABORATORIES | 2002-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103192-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC4 | HDAC1 1/4885HDAC2 7/4885HDAC3 6/4885 |
| US-20020177594-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC11, HDAC3 | HDAC1 1/4885HDAC2 4/4885HDAC3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.