Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.49 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KLK7 | P49862 | 2/20 | 0.45 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876274 | 1.00 | REN (0.49) | RENHTRA1MAPTKLK7KLK5 | |
| SCHEMBL9876624 | 0.93 | REN (0.49) | REN | |
| SCHEMBL9879690 | 0.92 | REN (0.48) | RENHTRA1MAPTKLK7KLK5 | |
| SCHEMBL10458260 | 0.91 | REN (0.50) | REN | |
| SCHEMBL7357503 | 0.89 | REN (0.52) | REN | |
| SCHEMBL9876300 | 0.86 | REN (0.50) | REN | |
| SCHEMBL9876626 | 0.81 | REN (0.56) | REN | |
| SCHEMBL10625927 | 0.80 | REN (0.46) | REN | |
| SCHEMBL10673839 | 0.80 | REN (0.46) | REN | |
| SCHEMBL10675537 | 0.80 | REN (0.46) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0270234-A2 | Renin inhibitors | PFIZER INC. (US) | 1988-06-08 | — | — | EP | disclosed |
| WO-1988003022-A1 | RELATIVELY LOW MOLECULAR WEIGHT POLYPEPTIDES AS RENIN INHIBITORS | PFIZER INC. (US) | 1988-05-05 | — | — | WO | disclosed |