Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | AGER | Q15109 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362876 | 0.88 | KDM4E (0.48) | KDM4ETDP1ALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL7365259 | 0.87 | TDP1 (0.53) | KDM4ETDP1ALDH1A1CYP3A4MAPT | |
| SCHEMBL7363321 | 0.87 | KDM4E (0.53) | KDM4ETDP1ALDH1A1CYP3A4MAPT | |
| SCHEMBL9375005 | 0.85 | KDM4E (0.50) | KDM4ETDP1ALDH1A1CYP3A4MAPT | |
| SCHEMBL7365358 | 0.84 | KDM4E (0.49) | KDM4ETDP1ALDH1A1L3MBTL1MCL1 | |
| SCHEMBL7370858 | 0.83 | KDM4E (0.48) | KDM4ETDP1ALDH1A1CYP3A4MAPT | |
| SCHEMBL27687569 | 0.76 | ACMSD (0.59) | MCL1DHODHACMSD | |
| SCHEMBL4094629 | 0.76 | KDM4E (0.61) | KDM4ETDP1ALDH1A1CYP3A4MAPT | |
| SCHEMBL912675 | 0.76 | KDM4E (0.77) | KDM4ETDP1ALDH1A1CYP3A4MAPT | |
| SCHEMBL31586013 | 0.76 | KDM4E (0.77) | KDM4ETDP1ALDH1A1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716954-A | ANTIINFLAMMATORY AGENT, ANTIHISTAMINES, IMMUNOSUPPRESSION,AUTOIMMUNE DISEASES | SYNTEX U.S.A. INC. (US) | 1998-02-10 | — | — | US | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |