Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340336 | 0.91 | KDR (0.52) | SMN1; SMN2NPC1RAB9ATSHRMAPT | |
| SCHEMBL7337256 | 0.90 | L3MBTL1 (0.48) | SMN1; SMN2NPC1RAB9AKMT2AMAPT | |
| SCHEMBL7341616 | 0.88 | L3MBTL1 (0.45) | SMN1; SMN2NPC1RAB9ATSHRKMT2A | |
| SCHEMBL7343900 | 0.87 | KMT2A (0.47) | NPC1RAB9AKMT2AGLAMAPT | |
| SCHEMBL7349946 | 0.86 | L3MBTL1 (0.46) | SMN1; SMN2NPC1RAB9ATSHRMAPT | |
| SCHEMBL7339623 | 0.84 | L3MBTL1 (0.46) | SMN1; SMN2RAB9AMAPTHTTL3MBTL1 | |
| SCHEMBL7349032 | 0.84 | L3MBTL1 (0.46) | SMN1; SMN2RAB9AMAPTHTTALDH1A1 | |
| SCHEMBL7337272 | 0.83 | L3MBTL1 (0.45) | SMN1; SMN2NPC1RAB9AMAPTHTT | |
| SCHEMBL7341988 | 0.83 | L3MBTL1 (0.45) | SMN1; SMN2RAB9AMAPTHTTL3MBTL1 | |
| SCHEMBL7341780 | 0.82 | TP53 (0.46) | SMN1; SMN2NPC1RAB9AKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | disclosed |