Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 7/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27275908 | 1.00 | GPBAR1 (0.47) | GPBAR1FKBP1ABRD4CREBBPHPGD | |
| SCHEMBL27047902 | 0.83 | HPGD (0.52) | FKBP1AHPGD | |
| SCHEMBL7442596 | 0.83 | ELANE (0.45) | GPBAR1FKBP1ABRD4CREBBPHPGD | |
| SCHEMBL22594386 | 0.81 | HTR2C (0.49) | FKBP1AHPGDTSHRGAAPKM | |
| SCHEMBL10137577 | 0.78 | FKBP1A (0.47) | FKBP1AHPGDTSHRHTR2C | |
| SCHEMBL23182808 | 0.77 | NPC1 (0.48) | FKBP1ANPC1RAB9A | |
| SCHEMBL11045622 | 0.77 | SMN1; SMN2 (0.50) | GPBAR1BRD4CREBBPGAAHTR2C | |
| SCHEMBL14299314 | 0.76 | FKBP1A (0.50) | FKBP1AHPGDTSHR | |
| SCHEMBL19258238 | 0.76 | FKBP1A (0.50) | FKBP1AHPGDTSHRHTR2C | |
| SCHEMBL13385271 | 0.76 | FKBP1A (0.50) | FKBP1AHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4665056-A | CENTRAL NERVOUS SYSTEM DISORDERS | TANABE SEIYAKU CO., LTD. (JP) | 1987-05-12 | — | — | US | disclosed |
| EP-0168042-A2 | Dihydroorotic acid derivatives, processes for their preparing and pharmaceutical composition containing them | TANABE SEIYAKU CO., LTD. (JP) | 1986-01-15 | — | — | EP | disclosed |