SCHEMBL7366249

SCHEMBL7366249

CCOC(=O)c1ccc(OCC2CCCN(C(=O)OC(C)(C)C)C2)cc1

nearest known ligand 0.74

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CHEK2 O96017 2/20 0.58
SCN9A Q15858 1/20 0.48
GPR119 Q8TDV5 4/20 0.48
HPGD P15428 1/20 0.47
ALOX5AP P20292 1/20 0.46
FEN1 P39748 1/20 0.46
MAPT P10636 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
ATM Q13315 1/20 0.45
KDM1A O60341 1/20 0.44
GRM3 Q14832 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14592667 0.94 GPR119 (0.52) CHEK2GPR119HPGDMAPTNPSR1
SCHEMBL29126576 0.90 GPR119 (0.47) CHEK2GPR119HPGDMAPTNPSR1
SCHEMBL7356793 0.88 CHEK2 (0.60) CHEK2SCN9AGPR119ALOX5APFEN1
SCHEMBL5827951 0.86 SCN9A (0.50) CHEK2SCN9AHPGDALOX5APFEN1
SCHEMBL3444142 0.85 CHEK2 (0.55) CHEK2SCN9AGPR119ALOX5APFEN1
SCHEMBL3444143 0.85 CHEK2 (0.55) CHEK2SCN9AGPR119ALOX5APFEN1
SCHEMBL1769253 0.85 CHEK2 (0.56) CHEK2SCN9AGPR119ALOX5APFEN1
SCHEMBL17729089 0.85 CHEK2 (0.56) CHEK2SCN9AGPR119ALOX5APFEN1
SCHEMBL3443787 0.85 CHEK2 (0.56) CHEK2SCN9AALOX5APFEN1KDM1A
SCHEMBL3443784 0.85 CHEK2 (0.56) CHEK2SCN9AALOX5APFEN1KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0714299-B1 BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS MERCK & CO INC (US) 2002-04-24 EP disclosed
EP-0805681-A4 TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS MERCK & CO INC (US) 1998-05-06 EP disclosed
EP-0805681-A1 TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 1997-11-12 EP disclosed
US-5665719-A Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists MERCK & CO., INC. (US) 1997-09-09 US disclosed
WO-1996022775-A1 TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1996-08-01 WO disclosed
EP-0714299-A4 1996-07-10 EP disclosed
EP-0714299-A1 BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS MERCK & CO. INC. (US) 1996-06-05 EP disclosed
WO-1995002405-A1 BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1995-01-26 WO disclosed