Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL891282 | 0.89 | EPHX1 (0.52) | EPHX1EPHX2GAAALDH1A1IDO1 | |
| Nitric Acid SCHEMBL4490937 | 0.88 | EPHX1 (0.51) | EPHX1EPHX2GAAALDH1A1IDO1 | |
| Hydrochloric Acid SCHEMBL9668292 | 0.88 | EPHX1 (0.50) | EPHX1EPHX2GAAALDH1A1IDO1 | |
| SCHEMBL4100753 | 0.80 | EPHX1 (0.58) | EPHX1EPHX2GAAALDH1A1IDO1 | |
| SCHEMBL13584612 | 0.79 | EPHX1 (0.59) | EPHX1EPHX2GAAALDH1A1IDO1 | |
| SCHEMBL29518499 | 0.79 | EPHX1 (0.59) | EPHX1EPHX2GAAALDH1A1IDO1 | |
| SCHEMBL10383506 | 0.79 | EPHX1 (0.51) | EPHX1EPHX2GAAALDH1A1CA2 | |
| Hydrochloric Acid SCHEMBL13584366 | 0.78 | EPHX1 (0.57) | EPHX1EPHX2GAAALDH1A1IDO1 | |
| SCHEMBL11139315 | 0.77 | EPHX1 (0.68) | EPHX1EPHX2GAAALDH1A1IDO1 | |
| SCHEMBL1995869 | 0.76 | EPHX1 (0.59) | EPHX1EPHX2GAAALDH1A1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992008464-A1 | SUBSTITUTED UREA AND RELATED CELL ADHESION MODULATION COMPOUNDS | TANABE SEIYAKU CO. LTD. (JP) | 1992-05-29 | — | — | WO | disclosed |