Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.72 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.72 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366920 | 0.91 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7296788 | 0.86 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7366684 | 0.84 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DHPGD | |
| SCHEMBL14412972 | 0.84 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DHPGD | |
| S-Rolipram SCHEMBL7398826 | 0.84 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| (-)-Rolipram SCHEMBL7638632 | 0.84 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7364241 | 0.83 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DHPGD | |
| SCHEMBL3545466 | 0.81 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7366341 | 0.81 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL3546000 | 0.81 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0584208-A4 | — | — | 1994-03-23 | — | — | EP | disclosed |
| EP-0584208-A1 | PYRROLIDINONES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-03-02 | — | — | EP | disclosed |
| WO-1992019594-A1 | PYRROLIDINONES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-11-12 | — | — | WO | disclosed |