Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6619305 | 1.00 | PDE4B (0.44) | PDE4BL3MBTL1KMT2AELANETMEM97 | |
| SCHEMBL6619271 | 1.00 | PDE4B (0.44) | PDE4BL3MBTL1KMT2AELANETMEM97 | |
| SCHEMBL4342264 | 0.94 | L3MBTL1 (0.46) | PDE4BL3MBTL1KMT2ATMEM97SIGMAR1 | |
| SCHEMBL4342257 | 0.94 | L3MBTL1 (0.46) | PDE4BL3MBTL1KMT2ATMEM97SIGMAR1 | |
| SCHEMBL4342256 | 0.94 | L3MBTL1 (0.46) | PDE4BL3MBTL1KMT2ATMEM97SIGMAR1 | |
| SCHEMBL6619512 | 0.93 | PDE4B (0.44) | PDE4BL3MBTL1KMT2AHTTCTSL | |
| SCHEMBL6623570 | 0.92 | PDE4B (0.47) | PDE4BL3MBTL1KMT2AHTTCTSL | |
| SCHEMBL6623564 | 0.92 | PDE4B (0.47) | PDE4BL3MBTL1KMT2AHTTCTSL | |
| SCHEMBL6623558 | 0.92 | PDE4B (0.47) | PDE4BL3MBTL1KMT2AHTTCTSL | |
| SCHEMBL2185018 | 0.88 | KMT2A (0.48) | PDE4BL3MBTL1KMT2AHTTCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6215002-B1 | CYCLIZATION, DEBLOCKING, DEPROTECTION, SULFONATION, CONDENSATION, AMIDATION; ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS | GLAXO WELLCOME INC. | 2001-04-10 | — | — | US | disclosed |
| EP-0891362-A1 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LIMITED (GB) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036903-A1 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LIMITED (GB) | 1997-10-09 | — | — | WO | disclosed |