SCHEMBL7366516

SCHEMBL7366516

CN[C@@H](Cc1ccc(-n2cncn2)cc1)C(=O)O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.43
ALDH1A1 P00352 2/20 0.43
KDM4E B2RXH2 1/20 0.43
MAPT P10636 2/20 0.43
HSP90AA1 P07900 1/20 0.43
HTT P42858 1/20 0.43
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
RAB9A P51151 2/20 0.40
NPC1 O15118 1/20 0.40
PDE2A O00408 1/20 0.39
DPP4 P27487 1/20 0.39
DPP8 Q6V1X1 1/20 0.39
POLB P06746 1/20 0.39
CYP11B2 P19099 1/20 0.38
ITGA4 P13612 1/20 0.38
SMYD3 Q9H7B4 1/20 0.38
BRS3 P32247 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16462491 0.83 SMN1; SMN2 (0.50) SMN1; SMN2ALDH1A1KDM4EMAPTHSP90AA1
SCHEMBL16254374 0.82 MAPT (0.44) SMN1; SMN2KDM4EMAPTCYP1A2CYP2D6
SCHEMBL7256083 0.79 CAPN1 (0.46) ALDH1A1KDM4EMAPTPDE2APPARG
Hydrochloric Acid SCHEMBL6574264 0.78 CAPN1 (0.45) ALDH1A1KDM4EMAPTPDE2APPARG
SCHEMBL5998963 0.76 SMN1; SMN2 (0.45) SMN1; SMN2ALDH1A1KDM4EMAPTHSP90AA1
SCHEMBL5998960 0.76 SMN1; SMN2 (0.45) SMN1; SMN2ALDH1A1KDM4EMAPTHSP90AA1
SCHEMBL8245526 0.75 SMN1; SMN2 (0.50) SMN1; SMN2ALDH1A1KDM4EMAPTHSP90AA1
SCHEMBL2657909 0.74 QPCT (0.56) SMN1; SMN2ALDH1A1KDM4EMAPTHSP90AA1
SCHEMBL9771673 0.74 CYP3A4 (0.48) ALDH1A1CYP1A2CYP2C9CYP2C19PPARG
SCHEMBL30404138 0.74 CYP3A4 (0.48) ALDH1A1CYP1A2CYP2C9CYP2C19PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997011960-A1 ANTAGONISTS OF ENDOTHELIN RECEPTORS JAPAT LTD. (CH) 1997-04-03 WO disclosed