Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.31 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.31 |
| ▸ | PDE6D | O43924 | 1/20 | 0.31 |
| ▸ | PDE8A | O60658 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | PDE6A | P16499 | 1/20 | 0.31 |
| ▸ | PDE6G | P18545 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | PDE6B | P35913 | 1/20 | 0.31 |
| ▸ | PDE6C | P51160 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7400390 | 0.72 | PDE5A (0.51) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL7432063 | 0.69 | PDE5A (0.37) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL7362347 | 0.69 | PDE5A (0.39) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL3671939 | 0.68 | PDE5A (0.55) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL7431615 | 0.68 | PDE5A (0.48) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL4653201 | 0.66 | PDE5A (0.47) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL7359529 | 0.64 | PDE5A (0.52) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL7395264 | 0.62 | PDE5A (0.54) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL7360299 | 0.61 | PDE5A (0.39) | PDE5APDE2AABCC4ABCC5PDE6D | |
| SCHEMBL7394374 | 0.61 | PDE5A (0.51) | PDE5APDE2AABCC4ABCC5PDE6D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001003644-A2 | PYRAZOLOPYRIMIDINONE DERIVATIVES CONJUGATED TO THIOPHENE MOIETIES OR BENZO [FUSED] 5-MEMBERED HETEROCYCLES FOR ERECTILE DYSFUNCTION | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) | 2001-01-18 | — | — | WO | claimed |
| WO-2001003644-A9 | PYRAZOLOPYRIMIDINONE DERIVATIVES CONJUGATED TO THIOPHENE MOIETIES OR BENZO [FUSED] 5-MEMBERED HETEROCYCLES FOR ERECTILE DYSFUNCTION | PICOWER INST MED RES (US) | 2001-11-29 | — | — | WO | disclosed |