Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL738069 | 0.92 | HRH3 (0.47) | KDM4EALDH1A1HRH3LMNAMAPT | |
| SCHEMBL2114689 | 0.90 | KDM4E (0.49) | KDM4EALDH1A1HRH3HTR7 | |
| SCHEMBL738472 | 0.90 | KDM4E (0.49) | KDM4EALDH1A1HRH3HTR7 | |
| SCHEMBL2006982 | 0.90 | HRH3 (0.48) | KDM4EALDH1A1HRH3LMNAMAPT | |
| SCHEMBL27711463 | 0.90 | HRH3 (0.48) | KDM4EALDH1A1HRH3LMNAMAPT | |
| SCHEMBL14685579 | 0.79 | SIGMAR1 (0.41) | KDM4EALDH1A1HRH3HTR7 | |
| SCHEMBL12449637 | 0.79 | KDM4E (0.51) | KDM4EALDH1A1HRH3LMNAMAPT | |
| SCHEMBL2115306 | 0.79 | SIGMAR1 (0.41) | KDM4EALDH1A1HRH3HTR7 | |
| SCHEMBL12449635 | 0.79 | KDM4E (0.51) | KDM4EALDH1A1HRH3LMNAMAPT | |
| SCHEMBL13003 | 0.79 | KDM4E (0.51) | KDM4EALDH1A1HRH3LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138206-B2 | Piperidine derivative | MSD. K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| US-20090137576-A1 | Novel Piperidine Derivative | MSD K.K. (JP) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137576-A1 | Novel Piperidine Derivative | HRH4, HRH3, HRH1 | KDM4E 1039/4885ALDH1A1 1242/4885HRH3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.