Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 7/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7404179 | 0.92 | PDE5A (0.48) | PDE5AROCK2ROCK1 | |
| SCHEMBL7397182 | 0.82 | PDE5A (0.60) | PDE5A | |
| SCHEMBL7397184 | 0.82 | PDE5A (0.60) | PDE5A | |
| Hydrochloric Acid SCHEMBL7389333 | 0.82 | KDM4E (0.46) | ROCK2ROCK1TSHRMAPK10 | |
| SCHEMBL7404535 | 0.81 | PDE5A (0.51) | PDE5A | |
| SCHEMBL7404538 | 0.81 | PDE5A (0.51) | PDE5A | |
| SCHEMBL7365450 | 0.80 | KDM4E (0.45) | ROCK2ROCK1TSHRMAPK10 | |
| SCHEMBL7365453 | 0.80 | KDM4E (0.45) | ROCK2ROCK1TSHRMAPK10 | |
| SCHEMBL7387641 | 0.80 | KDM4E (0.45) | ROCK2ROCK1TSHRMAPK10 | |
| SCHEMBL7565906 | 0.79 | ACHE (0.43) | PDE5ATSHRMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001030745-A1 | ANTHRANILIC ACID DERIVATIVES AS INHIBITORS OF THE CGMP-PHOSPHODIESTERASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-05-03 | — | — | WO | disclosed |