Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 7/20 | 0.44 |
| ▸ | PLG | P00747 | 5/20 | 0.44 |
| ▸ | PLAT | P00750 | 3/20 | 0.38 |
| ▸ | MMP1 | P03956 | 12/20 | 0.38 |
| ▸ | MMP13 | P45452 | 12/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7372430 | 0.91 | PLAU (0.44) | PLAUPLGPLATMMP1MMP13 | |
| SCHEMBL6965698 | 0.91 | PLAU (0.54) | PLAUPLGPLATMMP1MMP13 | |
| Hydrochloric Acid SCHEMBL6432636 | 0.90 | PLAU (0.53) | PLAUPLGPLATMMP1MMP13 | |
| SCHEMBL6438612 | 0.89 | PLAU (0.46) | PLAUPLGPLATMMP1MMP13 | |
| SCHEMBL7375080 | 0.84 | PLAU (0.54) | PLAUPLGPLAT | |
| SCHEMBL6968884 | 0.83 | PLAU (0.58) | PLAUPLGPLAT | |
| SCHEMBL6437182 | 0.82 | PLAU (0.52) | PLAUPLGPLATMMP1MMP13 | |
| SCHEMBL6438599 | 0.81 | PLAU (0.52) | PLAUPLGPLATMMP1MMP13 | |
| Hydrochloric Acid SCHEMBL6436707 | 0.81 | PLAU (0.51) | PLAUPLGPLATMMP1MMP13 | |
| SCHEMBL7367249 | 0.81 | PLAU (0.46) | PLAUPLGPLATMMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |