Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 15/20 | 0.71 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2555215 | 0.85 | AR (0.65) | ARTRPV4IDO1 | |
| SCHEMBL21466386 | 0.79 | AR (0.58) | ARTRPV4 | |
| SCHEMBL11875183 | 0.79 | AR (0.57) | ARTRPV4IDO1MRGPRX4 | |
| SCHEMBL28994622 | 0.78 | AR (0.45) | ARPTGES | |
| SCHEMBL6474353 | 0.78 | AR (0.49) | ARTRPV4 | |
| SCHEMBL952338 | 0.77 | AR (0.65) | ARTRPV4MRGPRX4 | |
| SCHEMBL10600692 | 0.76 | TSHR (0.56) | AR | |
| SCHEMBL24480294 | 0.73 | AR (0.44) | AR | |
| SCHEMBL29580065 | 0.73 | AR (0.44) | AR | |
| SCHEMBL30602891 | 0.73 | AR (0.44) | ARPTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| CN-1254335-A | Nicotinamide derivatives | PFIZER PROD INC (US) | 2000-05-24 | — | — | CN | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |