Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.62 |
| ▸ | ITGAV | P06756 | 20/20 | 0.62 |
| ▸ | ITGB6 | P18564 | 9/20 | 0.62 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.60 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.58 |
| ▸ | ITGB5 | P18084 | 7/20 | 0.58 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.51 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.51 |
| ▸ | ITGA8 | P53708 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367565 | 0.90 | ITGB3 (0.55) | ITGB3ITGAVITGB6ITGA2BITGB1 | |
| SCHEMBL7449770 | 0.89 | ITGB3 (0.59) | ITGB3ITGAVITGB6ITGA2BITGB1 | |
| SCHEMBL7450003 | 0.88 | ITGB3 (0.60) | ITGB3ITGAVITGB6ITGA2BITGB1 | |
| SCHEMBL7340047 | 0.86 | ITGB3 (0.62) | ITGB3ITGAVITGB6ITGA2BITGB1 | |
| SCHEMBL7349856 | 0.86 | ITGB3 (0.46) | ITGB3ITGAVITGB6ITGA2BITGB1 | |
| SCHEMBL7340415 | 0.85 | ITGB3 (0.46) | ITGB3ITGAVITGB6ITGA2BITGB1 | |
| SCHEMBL23489521 | 0.81 | ITGB3 (0.60) | ITGB3ITGAVITGB6ITGA2BITGB1 | |
| SCHEMBL30073964 | 0.81 | ITGB3 (0.60) | ITGB3ITGAVITGB6ITGA2BITGB1 | |
| SCHEMBL7372242 | 0.79 | ITGB3 (0.56) | ITGB3ITGAVITGB6ITGA2BITGB1 | |
| SCHEMBL4336179 | 0.78 | SMN1; SMN2 (0.41) | ITGB3ITGAVITGB6ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |