Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17581946 | 0.69 | BRD4 (0.38) | BRD4KDM4E | |
| SCHEMBL7366331 | 0.69 | KMT2A (0.43) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL1135190 | 0.68 | — | — | |
| SCHEMBL11144982 | 0.67 | HRH3 (0.54) | HRH3L3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL10687555 | 0.67 | HRH3 (0.44) | BRD4HRH3KDM4EALDH1A1RAB9A | |
| SCHEMBL11405317 | 0.66 | HRH3 (0.52) | HRH3L3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL11397982 | 0.65 | ALDH1A1 (0.45) | BRD4HRH3KDM4EALDH1A1RAB9A | |
| SCHEMBL958356 | 0.65 | — | — | |
| Dimethylamine SCHEMBL10680236 | 0.64 | HRH3 (0.47) | HRH3RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL15541217 | 0.64 | BRD4 (0.43) | BRD4HRH3KDM4EALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |