Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.56 |
| ▸ | PDE4A | P27815 | 7/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.56 |
| ▸ | CTSK | P43235 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367832 | 1.00 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DCTSK | |
| SCHEMBL6318372 | 0.88 | APP (0.59) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7370998 | 0.84 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4DCTSK | |
| SCHEMBL7367510 | 0.84 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4DCTSK | |
| SCHEMBL7367513 | 0.84 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4DCTSK | |
| SCHEMBL7371000 | 0.84 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4DCTSK | |
| SCHEMBL7366496 | 0.84 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4DCTSK | |
| SCHEMBL7366497 | 0.84 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4DCTSK | |
| SCHEMBL6865615 | 0.76 | PDE4D (0.60) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7367064 | 0.75 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994027947-A1 | PHENYLCYCLOPROPANE COMPOUNDS AND THEIR USE AS cAMP AND TNF INHIBITORS | RHONE-POULENC RORER LTD. (GB) | 1994-12-08 | — | — | WO | claimed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |
| WO-1994027947-A1 | PHENYLCYCLOPROPANE COMPOUNDS AND THEIR USE AS cAMP AND TNF INHIBITORS | RHONE-POULENC RORER LTD. (GB) | 1994-12-08 | — | — | WO | disclosed |