Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.62 |
| ▸ | PDE4A | P27815 | 12/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.62 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367938 | 1.00 | MAPT (0.64) | MAPTLMNAPDE4BPDE4APDE4C | |
| SCHEMBL7364522 | 0.86 | PDE4B (0.67) | MAPTLMNAPDE4BPDE4APDE4C | |
| SCHEMBL7333823 | 0.83 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7355649 | 0.83 | PDE4B (0.82) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL783250 | 0.79 | MAPT (1.00) | MAPTLMNAALDH1A1HPGDABCG2 | |
| SCHEMBL805341 | 0.79 | MAPT (1.00) | MAPTLMNAALDH1A1HPGDABCG2 | |
| SCHEMBL5030807 | 0.79 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL10780014 | 0.79 | PDE4B (0.65) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL9187839 | 0.78 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7360000 | 0.78 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459145-A | Calcium independent camp phosphodiesterase inhibitor antidepressant | PFIZER INC. (US) | 1995-10-17 | — | — | US | disclosed |
| US-5294730-A | A-Amino-4-alkoxy-3-polycycloalkyloxybenzyl cyanide derivatives | PFIZER INC. (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0247725-B1 | Calcium independent camp phosphodiestrerase inhibitor antidepressant | PFIZER (US) | 1994-03-02 | — | — | EP | disclosed |
| US-5196426-A | CALCIUM INDEPENDENT C AMP PHOSPHODIESTERASE INHIBITOR ANTIDEPRESSANT | PFIZER INC. (US) | 1993-03-23 | — | — | US | disclosed |
| US-5128358-A | Aryl substituted nitrogen heterocyclic antidepressants | PFIZER INC. (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0247725-A2 | Calcium independent camp phosphodiestrerase inhibitor antidepressant | PFIZER INC. (US) | 1987-12-02 | — | — | EP | disclosed |
| WO-1987006576-A1 | CALCIUM INDEPENDENT CAMP PHOSPHODIESTERASE INHIBITOR ANTIDEPRESSANT | PFIZER INC. (US) | 1987-11-05 | — | — | WO | disclosed |