Sugi Predict

Sugi Predict / Compounds / SCHEMBL805341

SCHEMBL805341

SCHEMBL805341

COc1ccc(C(=O)/C=C/N(C)C)cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 6/20 1.00
▸ LMNA P02545 4/20 1.00
▸ ABCG2 Q9UNQ0 6/20 0.65
▸ ALDH1A1 P00352 3/20 0.64
▸ HPGD P15428 1/20 0.64
▸ TNFRSF1A P19438 2/20 0.60
▸ ABCB1 P08183 2/20 0.60
▸ MEN1 O00255 3/20 0.57
▸ KMT2A Q03164 3/20 0.57
▸ NPC1 O15118 1/20 0.57
▸ USP2 O75604 1/20 0.57
▸ MAPK1 P28482 1/20 0.57
▸ ATM Q13315 1/20 0.57
▸ NPSR1 Q6W5P4 1/20 0.57
▸ CYP1A2 P05177 1/20 0.56
▸ CYP3A4 P08684 1/20 0.56
▸ CYP2C9 P11712 1/20 0.56
▸ TSHR P16473 1/20 0.56
▸ CYP2C19 P33261 1/20 0.56
▸ KDM4E B2RXH2 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL783250 1.00 MAPT (1.00) MAPTLMNAABCG2ALDH1A1HPGD
SCHEMBL801281 0.88 MAPT (0.78) MAPTLMNAABCG2ALDH1A1HPGD
SCHEMBL16911749 0.88 MAPT (0.78) MAPTLMNAABCG2ALDH1A1HPGD
SCHEMBL15777949 0.88 MAPT (0.78) MAPTLMNAABCG2ALDH1A1HPGD
SCHEMBL16627905 0.88 MAPT (0.78) MAPTLMNAABCG2ALDH1A1HPGD
SCHEMBL3603472 0.87 MAPT (0.77) MAPTLMNAABCG2ALDH1A1HPGD
SCHEMBL3603468 0.87 MAPT (0.77) MAPTLMNAABCG2ALDH1A1HPGD
SCHEMBL24370978 0.86 MAPT (0.76) MAPTLMNAABCG2ALDH1A1HPGD
SCHEMBL16628019 0.86 MAPT (0.76) MAPTLMNAABCG2ALDH1A1HPGD
SCHEMBL15779262 0.86 MAPT (0.76) MAPTLMNAABCG2ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11827640-B2 Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators ILDONG PHARMACEUTICAL CO., LTD. (KR) 2023-11-28 — — US disclosed
US-11827640-B2 Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators ILDONG PHARMACEUTICAL CO., LTD. (KR) 2023-11-28 — — US disclosed
CN-116348468-A CFTR modulator compounds, compositions and uses thereof 日东制药株式会社 2023-06-27 — — CN disclosed
WO-2023067388-A1 USES OF CFTR MODULATOR AND/OR PDE4 INHIBITOR COMPOUNDS ILDONG PHARMACEUTICAL CO., LTD. (KR) 2023-04-27 — — WO disclosed
WO-2022084741-A1 CFTR MODULATOR COMPOUNDS, COMPOSITIONS, AND USES THEREOF ILDONG PHARMACEUTICAL CO., LTD. (KR) 2022-04-28 — — WO disclosed
EP-2959898-A1 4,5-DIOXO-NAPHTHO[1,2-b]FURANS AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS Sloan-Kettering Institute for Cancer Research (US) 2015-12-30 — — EP disclosed
EP-2427057-B1 BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS SLOAN KETTERING INST CANCER (US) 2015-08-12 — — EP disclosed
US-20120071523-A1 BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2012-03-22 — — US disclosed
WO-2010129049-A1 BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2010-11-11 — — WO disclosed
US-7723348-B2 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORPORATION (US) 2010-05-25 — — US disclosed
US-20080207660-A1 PHOSPHODIESTERASE 4 INHIBITORS HOPPER ALLEN 2008-08-28 — — US disclosed
WO-2007123953-A2 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2007-11-01 — — WO disclosed
US-20070254913-A1 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORPORATION 2007-11-01 — — US disclosed
EP-1799673-A1 PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS Memory Pharmaceuticals Corporation (US) 2007-06-27 — — EP disclosed
US-20060154960-A1 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORPORATION 2006-07-13 — — US disclosed
WO-2006044528-A1 PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2006-04-27 — — WO disclosed
US-4904658-A Substituted-6H,8H-pyrimido-[1,2,3-cd]purine-8,10-(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones AMERICAN CYANAMID COMPANY (US) 1990-02-27 — — US disclosed
US-4888345-A HYPOTENSIVE AND ANXIOLYTIC AGENTS; CHEMICAL INTERMEDIATES AMERICAN CYANAMID COMPANY (US) 1989-12-19 — — US disclosed
US-4236005-A ANTIANXIETY AMERICAN CYANAMID COMPANY (US) 1980-11-25 — — US disclosed
US-4178449-A Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines AMERICAN CYANAMID COMPANY (US) 1979-12-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11827640-B2 Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators PDE4A, PDE4B, PDE5A MAPT 4661/4885LMNA 4118/4885ABCG2 154/4885
US-20070254913-A1 Phosphodiesterase 4 inhibitors PDE4A, PDE4B, PDE12 MAPT 3815/4885LMNA 3738/4885ABCG2 379/4885
US-20080207660-A1 PHOSPHODIESTERASE 4 INHIBITORS PDE4A, PDE4B, PDE12 MAPT 3815/4885LMNA 3738/4885ABCG2 379/4885
US-20060154960-A1 Phosphodiesterase 4 inhibitors PDE4A, PDE4B, PDE12 MAPT 3815/4885LMNA 3738/4885ABCG2 379/4885
US-20120071523-A1 BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS PDF, EIF5B, EIF4E MAPT 3128/4885LMNA 3542/4885ABCG2 1427/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.