Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368119 | 0.85 | HRH3 (0.46) | SIGMAR1L3MBTL3HRH3CYP1A2CYP2D6 | |
| SCHEMBL2265000 | 0.85 | HRH3 (0.50) | SIGMAR1L3MBTL3HRH3CYP1A2CYP2D6 | |
| SCHEMBL7369081 | 0.84 | CXCR4 (0.53) | CXCR4HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL7369687 | 0.84 | CYP1A2 (0.51) | SIGMAR1L3MBTL3HRH3CYP1A2CYP2D6 | |
| SCHEMBL7369693 | 0.81 | SIGMAR1 (0.41) | SIGMAR1POLBCXCR4HRH3CYP1A2 | |
| SCHEMBL946684 | 0.77 | SIGMAR1 (0.42) | SIGMAR1POLBHRH3MAPK1CYP1A2 | |
| SCHEMBL953075 | 0.76 | SIGMAR1 (0.48) | SIGMAR1ALDH1A1KCNH2 | |
| SCHEMBL422200 | 0.75 | SIGMAR1 (0.56) | SIGMAR1L3MBTL3POLBHRH3KCNH2 | |
| SCHEMBL950571 | 0.75 | HRH3 (0.51) | SIGMAR1HRH3MAPK1CYP1A2ALDH1A1 | |
| SCHEMBL1771953 | 0.75 | CYP1A2 (0.49) | SIGMAR1CYP1A2ALDH1A1CHRM1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235829-A2 | PYRAZOLO 1,5-D] 1,2,4]TRIAZINES FOR ENHANCING COGNITION | MERCK SHARP & DOHME LTD. (GB) | 2002-09-04 | — | — | EP | disclosed |
| US-6355638-B1 | COGNITION ACTIVATORS | MERCK SHARP & DOHME LTD. (GB) | 2002-03-12 | — | — | US | disclosed |
| WO-2001038331-A2 | PYRAZOLO[1,5-D][1,2,4]TRIAZINES FOR ENHANCING COGNITION | MERCK SHARP & DOHME LIMITED (GB) | 2001-05-31 | — | — | WO | disclosed |