Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 10/20 | 0.51 |
| ▸ | CA7 | P43166 | 10/20 | 0.51 |
| ▸ | CA9 | Q16790 | 10/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 10/20 | 0.51 |
| ▸ | CA1 | P00915 | 9/20 | 0.51 |
| ▸ | CA2 | P00918 | 8/20 | 0.51 |
| ▸ | TYR | P14679 | 4/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 5/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 4/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.47 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368086 | 1.00 | CA12 (0.51) | CA12CA7CA9CA14CA1 | |
| SCHEMBL7368082 | 1.00 | CA12 (0.51) | CA12CA7CA9CA14CA1 | |
| SCHEMBL9997865 | 0.86 | MAPT (0.44) | CA12CA7CA9CA14CA1 | |
| SCHEMBL9997863 | 0.86 | MAPT (0.44) | CA12CA7CA9CA14CA1 | |
| SCHEMBL9997357 | 0.84 | HSD11B1 (0.47) | MAOBCYP2C9HSD11B1MEN1LMNA | |
| SCHEMBL5756310 | 0.84 | CYP1A2 (0.47) | MAOBPTGS2ALDH1A1LMNACYP1A2 | |
| SCHEMBL9997355 | 0.84 | HSD11B1 (0.47) | MAOBCYP2C9HSD11B1MEN1LMNA | |
| SCHEMBL9516822 | 0.84 | MAPT (0.45) | MAOBCYP2C9CYP2D6MMP2MMP9 | |
| SCHEMBL29034774 | 0.84 | CACNA1B (0.39) | CA12CA7CA9CA14CA1 | |
| SCHEMBL5756315 | 0.84 | CYP1A2 (0.47) | MAOBPTGS2ALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5137889-A | Hypotensive agents; coronary vasodilators; calcium antagonists; antiinflammatory agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-08-11 | — | — | US | disclosed |
| US-5034395-A | Hypotensive agents, carboxylated dihydropyridines | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-23 | — | — | US | disclosed |
| EP-0145434-A2 | Novel dihydropyridine derivatives and process for preparing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-19 | — | — | EP | disclosed |