Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | PDE5A | O76074 | 14/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | PDE6D | O43924 | 1/20 | 0.45 |
| ▸ | PDE9A | O76083 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PDE6A | P16499 | 1/20 | 0.45 |
| ▸ | PDE6G | P18545 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL149188 | 0.89 | KMT2A (0.48) | KDM4EPDE5AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL9370768 | 0.88 | KDM4E (0.46) | KDM4EPDE5AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL4066455 | 0.85 | KDM4E (0.53) | KDM4EALDH1A1SMN1; SMN2GAARXFP1 | |
| SCHEMBL9376126 | 0.84 | PDE5A (0.45) | KDM4EPDE5AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7645372 | 0.82 | KMT2A (0.53) | KDM4EPDE5AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL9370220 | 0.80 | PDE5A (0.47) | KDM4EPDE5AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL9295923 | 0.80 | PDE5A (0.57) | KDM4EPDE5AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7643686 | 0.79 | PDE5A (0.45) | KDM4EPDE5AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL9370740 | 0.79 | PDE5A (0.44) | KDM4EPDE5AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7365111 | 0.79 | PDE5A (0.46) | KDM4EPDE5AALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347027-B1 | Phenylpyridone derivatives,processes for their preparation and pharmaceutical compositions containing them. | SMITH KLINE FRENCH LAB (GB) | 1994-08-03 | — | — | EP | claimed |
| EP-0347027-A2 | Phenylpyridone derivatives,processes for their preparation and pharmaceutical compositions containing them. | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-12-20 | — | — | EP | claimed |
| US-6479520-B1 | REGULATING APOPTOSIS IN HUMAN CELLS WITH COMPOUNDS SUCH AS: 3-CYANO-6-(2-METHOXY-4-METHYLTHIOIPHENYL)-2(1H)-PYRIDINONE | CELL PATHWAYS, INC. | 2002-11-12 | — | — | US | disclosed |
| US-6046216-A | USEFUL TO INHIBIT THE GROWTH OF NEOPLASTIC CELLS. | CELL PATHWAYS, INC. (US) | 2000-04-04 | — | — | US | disclosed |
| WO-1999059584-A1 | COMBINATION OF PHENTOLAMINE AND CYCLIC GMP PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | SCHERING CORPORATION (US) | 1999-11-25 | — | — | WO | disclosed |
| EP-0347027-B1 | Phenylpyridone derivatives,processes for their preparation and pharmaceutical compositions containing them. | SMITH KLINE FRENCH LAB (GB) | 1994-08-03 | — | — | EP | disclosed |
| US-5254571-A | Bronchodilators, antiallergens | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0347027-A2 | Phenylpyridone derivatives,processes for their preparation and pharmaceutical compositions containing them. | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-12-20 | — | — | EP | disclosed |