Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368255 | 0.85 | KDM4E (0.51) | KDM4EALDH1A1SMN1; SMN2GAARXFP1 | |
| SCHEMBL6042680 | 0.77 | ALDH1A1 (0.63) | KDM4EALDH1A1SMN1; SMN2HRH1HTR1B | |
| SCHEMBL7645372 | 0.76 | KMT2A (0.53) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL149188 | 0.75 | KMT2A (0.48) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7131872 | 0.74 | KDM4E (0.55) | KDM4EALDH1A1SMN1; SMN2HTR7HRH1 | |
| SCHEMBL9370768 | 0.74 | KDM4E (0.46) | KDM4EALDH1A1SMN1; SMN2GAAADRB2 | |
| SCHEMBL7225494 | 0.73 | KDM4E (0.71) | KDM4EALDH1A1SMN1; SMN2HTR7HRH1 | |
| SCHEMBL7944215 | 0.72 | HTR7 (0.70) | KDM4EALDH1A1SMN1; SMN2HTR7ADRB2 | |
| SCHEMBL7646422 | 0.72 | GUSB (0.44) | KDM4EALDH1A1RXFP1 | |
| SCHEMBL7276461 | 0.71 | KDM4E (0.63) | KDM4EALDH1A1SMN1; SMN2GAARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761268-A4 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-07-08 | — | — | EP | disclosed |
| EP-1768983-A2 | FUSED HETEROCYCLIC KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2007-04-04 | — | — | EP | disclosed |
| EP-1761268-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006004636-A2 | FUSED HETEROCYCLIC KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-01-12 | — | — | WO | disclosed |
| WO-2006004833-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-01-12 | — | — | WO | disclosed |