SCHEMBL7368637

SCHEMBL7368637

O=c1c(Cl)coc2cc(OCCCCl)ccc12

nearest known ligand 0.52

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.52
ALDH1A1 P00352 2/20 0.52
MAPT P10636 2/20 0.52
NPC1 O15118 1/20 0.52
HPGD P15428 1/20 0.52
HSD17B10 Q99714 1/20 0.52
ALDH2 P05091 18/20 0.51
MAOA P21397 11/20 0.51
MAOB P27338 11/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7376791 0.84 ALDH2 (0.50) MAPTNPC1ALDH2MAOAMAOB
SCHEMBL7372448 0.82 PTPN1 (0.51) ALDH2MAOAMAOB
SCHEMBL7370694 0.82 ALDH2 (0.54) ALDH2MAOAMAOB
SCHEMBL7893822 0.81 ALDH2 (0.52) ALDH2MAOAMAOB
SCHEMBL8983873 0.80 MAPT (0.67) KDM4EALDH1A1MAPTNPC1HPGD
SCHEMBL7373528 0.78 KDM4E (0.62) KDM4EMAOAMAOB
SCHEMBL10519865 0.74 KDM4E (0.60) KDM4EMAOAMAOB
SCHEMBL8786602 0.72 ALDH2 (0.48) ALDH2MAOAMAOB
SCHEMBL28776653 0.72 KDM4E (0.62) KDM4EMAOAMAOB
SCHEMBL25273764 0.71 ALDH2 (0.64) ALDH2MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0699197-B1 4-P-FLUOROBENZOYL-1-PIPERIDINYL-PROPOXY-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF PSYCHOSIS AND SCHIZOPHRENIA FERRER INT (ES) 2000-06-07 EP disclosed
US-5643927-A METHOD OF PREPARATION BY DEHYDROCHLORINATION BETWEEN 4-(P-FLUOROBENZOYLPIPERIDINE WITH CHLOROALKYLCHROMEN-4-ONE FERRER INTERNACIONAL, S.A. (ES) 1997-07-01 US disclosed
EP-0699197-A1 4-P-FLUOROBENZOYL-1-PIPERIDINYL-PROPOXY-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF PSYCHOSIS AND SCHIZOPHRENIA FERRER INTERNACIONAL, S.A. (ES) 1996-03-06 EP disclosed
WO-1995025733-A1 4-P-FLUOROBENZOYL-1-PIPERIDINYL-PROPOXY-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF PSYCHOSIS AND SCHIZOPHRENIA FERRER INTERNACIONAL, S.A. (ES) 1995-09-28 WO disclosed