SCHEMBL7370694

SCHEMBL7370694

O=c1c(CO)coc2cc(OCCCCl)ccc12

nearest known ligand 0.54

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH2 P05091 17/20 0.54
MAOB P27338 11/20 0.54
MAOA P21397 10/20 0.54
CHRM2 P08172 1/20 0.51
CHRM4 P08173 1/20 0.51
CHRM5 P08912 1/20 0.51
CHRM1 P11229 1/20 0.51
CHRM3 P20309 1/20 0.51
DRD4 P21917 1/20 0.51
DRD3 P35462 1/20 0.51
SIGMAR1 Q99720 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7368637 0.82 KDM4E (0.52) ALDH2MAOBMAOA
SCHEMBL7376791 0.81 ALDH2 (0.50) ALDH2MAOBMAOA
SCHEMBL11618513 0.81 CYP11B1 (0.64) MAOBMAOA
SCHEMBL7893822 0.81 ALDH2 (0.52) ALDH2MAOBMAOA
SCHEMBL8983873 0.80 MAPT (0.67) ALDH2MAOBMAOA
SCHEMBL21591464 0.80 MAOB (0.57) MAOBMAOA
SCHEMBL7372448 0.79 PTPN1 (0.51) ALDH2MAOBMAOA
SCHEMBL11620426 0.76 MAOB (0.63) ALDH2MAOBMAOA
SCHEMBL7373528 0.75 KDM4E (0.62) MAOBMAOASIGMAR1
SCHEMBL21591575 0.74 MAOB (0.65) ALDH2MAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0765323-B1 4-(6-FLUORO-1,2-BENZISOXAZOLYL)-1-PIPERIDINYL-PROPOXY-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF PSYCHOSIS, SCHIZOPHRENIA AND ANXIETY FERRER INT (ES) 2001-07-11 EP disclosed
EP-0699197-B1 4-P-FLUOROBENZOYL-1-PIPERIDINYL-PROPOXY-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF PSYCHOSIS AND SCHIZOPHRENIA FERRER INT (ES) 2000-06-07 EP disclosed
US-5736558-A 4-(6-fluoro-1,2-benzisoxazolyl)-1 piperidinyl-propoxy-chromen-4-one-one-derivatives, their preparation and their use in the treatment of psychosis, schizophrenia and anxiety FERRER INTERNACIONAL, S.A. (ES) 1998-04-07 US disclosed
US-5643927-A METHOD OF PREPARATION BY DEHYDROCHLORINATION BETWEEN 4-(P-FLUOROBENZOYLPIPERIDINE WITH CHLOROALKYLCHROMEN-4-ONE FERRER INTERNACIONAL, S.A. (ES) 1997-07-01 US disclosed
EP-0765323-A1 4-(6-FLUORO-1,2-BENZISOXAZOLYL)-1-PIPERIDINYL-PROPOXY-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF PSYCHOSIS, SCHIZOPHRENIA AND ANXIETY FERRER INTERNACIONAL, S.A. (ES) 1997-04-02 EP disclosed
WO-1996032389-A1 4-(6-FLUORO-1,2-BENZISOXAZOLYL)-1-PIPERIDINYL-PROPOXY-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF PSYCHOSIS, SCHIZOPHRENIA AND ANXIETY FERRER INTERNACIONAL, S.A. (ES) 1996-10-17 WO disclosed
EP-0699197-A1 4-P-FLUOROBENZOYL-1-PIPERIDINYL-PROPOXY-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF PSYCHOSIS AND SCHIZOPHRENIA FERRER INTERNACIONAL, S.A. (ES) 1996-03-06 EP disclosed
WO-1995025733-A1 4-P-FLUOROBENZOYL-1-PIPERIDINYL-PROPOXY-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF PSYCHOSIS AND SCHIZOPHRENIA FERRER INTERNACIONAL, S.A. (ES) 1995-09-28 WO disclosed