Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363107 | 0.87 | MAPK8 (0.83) | MAPK8ALDH1A1 | |
| SCHEMBL7370313 | 0.83 | MAPK8 (0.67) | MAPK8 | |
| SCHEMBL7369449 | 0.83 | MAPK8 (0.63) | LMNAMAPK8ALDH1A1HPGD | |
| SCHEMBL7366565 | 0.83 | MAPK8 (0.73) | LMNAMAPK8ALDH1A1HPGD | |
| SCHEMBL30989915 | 0.82 | LMNA (0.80) | LMNAMAPK8ALDH1A1GAAHPGD | |
| SCHEMBL7363366 | 0.81 | MAPK8 (0.55) | LMNAMAPK8ALDH1A1 | |
| SCHEMBL7450186 | 0.81 | MAPK8 (0.55) | LMNAMAPK8ALDH1A1 | |
| SCHEMBL7369138 | 0.80 | MAPK8 (0.69) | LMNAMAPK8ALDH1A1HPGD | |
| SCHEMBL7364353 | 0.79 | HPGD (0.68) | LMNAMAPK8GAAHPGD | |
| SCHEMBL7366862 | 0.78 | MAPK8 (0.56) | MAPK8ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |