Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.67 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BRS3 | P32247 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 3/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1384813 | 0.80 | NOTUM (1.00) | NOTUMMAP2K1GAAMAPTALDH1A1 | |
| SCHEMBL7368040 | 0.80 | NOTUM (0.62) | NOTUMMAP2K1GAAMMP1ALDH1A1 | |
| SCHEMBL5674033 | 0.79 | NOTUM (0.67) | NOTUMMAP2K1MEN1KMT2AGAA | |
| SCHEMBL8535240 | 0.77 | NOTUM (0.68) | NOTUMMAP2K1MMP1ALDH1A1CYP1A1 | |
| SCHEMBL17488164 | 0.76 | NOTUM (0.62) | NOTUMMAP2K1ALDH1A1BRS3GCK | |
| SCHEMBL11226843 | 0.75 | NOTUM (0.67) | NOTUMMAP2K1MAPTMAPK1CDK1 | |
| Hydrochloric Acid SCHEMBL31700388 | 0.75 | NOTUM (0.60) | NOTUMMAP2K1GAAMAPTBRS3 | |
| SCHEMBL26033405 | 0.75 | NOTUM (0.60) | NOTUMMAP2K1MEN1KMT2AMAPT | |
| SCHEMBL26953393 | 0.75 | NOTUM (0.55) | NOTUMMAP2K1BRS3CA12CA9 | |
| SCHEMBL3072721 | 0.75 | NOTUM (0.66) | NOTUMMAP2K1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613467-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1994-09-07 | — | — | EP | disclosed |
| WO-1993010093-A1 | 2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-05-27 | — | — | WO | disclosed |