Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | BRAF | P15056 | 14/20 | 0.59 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.50 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.50 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360041 | 0.85 | KDM4E (0.75) | KDM4EBRAFDYRK1BTLR8 | |
| SCHEMBL7362754 | 0.84 | KDM4E (0.68) | KDM4EBRAFTLR8 | |
| SCHEMBL7369441 | 0.84 | KDM4E (0.71) | KDM4EBRAFTLR8 | |
| SCHEMBL7361109 | 0.84 | KDM4E (0.74) | KDM4EBRAFDYRK1BTLR8 | |
| SCHEMBL7402736 | 0.83 | KDM4E (0.67) | KDM4EBRAFTLR8 | |
| SCHEMBL7365839 | 0.83 | KDM4E (0.50) | KDM4EBRAFDYRK1BTLR8MAPK13 | |
| SCHEMBL7404980 | 0.83 | KDM4E (0.66) | KDM4EBRAFTLR8MAPK13PIM1 | |
| SCHEMBL7370603 | 0.81 | KDM4E (0.67) | KDM4EBRAFTLR8 | |
| SCHEMBL3172240 | 0.81 | KDM4E (0.80) | KDM4EBRAFTLR8 | |
| SCHEMBL3175469 | 0.81 | KDM4E (0.83) | KDM4EBRAFDYRK1BTLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4521422-A | ANTICONVULSANT, ANTIEPILEPTIC AGENTS, SEDATIVES, MUSCLE RELAXANTS | AMERICAN CYANAMID COMPANY (US) | 1985-06-04 | — | — | US | disclosed |
| EP-0129847-A2 | Aryl and heteroaryl[7-(aryl and heteroaryl)-pyrazolo-[1,5-a]-pyrimidin-3-yl]methanones | AMERICAN CYANAMID COMPANY (US) | 1985-01-02 | — | — | EP | disclosed |