SCHEMBL7369223

SCHEMBL7369223

C=CCC(=O)NC(CC(=O)OC)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TACR3 P29371 1/20 0.46
KMT2A Q03164 3/20 0.46
MEN1 O00255 2/20 0.46
POLB P06746 1/20 0.46
ALDH1A1 P00352 5/20 0.43
ROCK2 O75116 2/20 0.43
ROCK1 Q13464 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
LMNA P02545 1/20 0.43
TSHR P16473 1/20 0.42
RAB9A P51151 1/20 0.42
KCNA5 P22460 1/20 0.41
HTT P42858 1/20 0.40
NCOA1 Q15788 1/20 0.40
NCOA3 Q9Y6Q9 1/20 0.40
MAPT P10636 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
HPGD P15428 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8595423 0.85 SMN1; SMN2 (0.49) POLBALDH1A1SMN1; SMN2LMNAHTT
SCHEMBL4238564 0.84 KMT2A (0.51) TACR3KMT2AMEN1POLBALDH1A1
SCHEMBL15170380 0.81 KMT2A (0.53) TACR3KMT2AMEN1POLBALDH1A1
SCHEMBL15170378 0.81 KMT2A (0.53) TACR3KMT2AMEN1POLBALDH1A1
SCHEMBL1460374 0.79 KMT2A (0.55) TACR3KMT2AMEN1POLBALDH1A1
SCHEMBL20993380 0.79 KMT2A (0.52) TACR3KMT2AMEN1POLBALDH1A1
SCHEMBL1144523 0.79 KMT2A (0.55) TACR3KMT2AMEN1POLBALDH1A1
SCHEMBL16348950 0.79 KMT2A (0.55) TACR3KMT2AMEN1POLBALDH1A1
SCHEMBL12175411 0.79 TACR3 (0.47) TACR3KMT2AMEN1POLBALDH1A1
SCHEMBL13912227 0.77 GPR88 (0.50) TACR3KMT2AMEN1POLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0730590-B1 ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS DU PONT PHARM CO (US) 2001-01-17 EP disclosed
US-6114328-A ANTICOAGULANTS; BLOOD DISORDERS DUPONT PHARMACEUTICALS COMPANY (US) 2000-09-05 US disclosed
EP-0970950-A2 Novel isoxazoline and isoxazole fibrinogen receptor antagonists DuPont Pharmaceuticals Company (US) 2000-01-12 EP disclosed
US-5849736-A Isoxazoline and isoxazole fibrinogen receptor antagonists THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1998-12-15 US disclosed
EP-0832076-A1 NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1998-04-01 EP disclosed
WO-1996038426-A1 NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-12-05 WO disclosed
EP-0730590-A1 NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-09-11 EP disclosed
WO-1995014683-A1 NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1995-06-01 WO disclosed