Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | PDE4A | P27815 | 4/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364352 | 0.88 | KMT2A (0.48) | MEN1KMT2AMAPTNPSR1GAA | |
| SCHEMBL7368635 | 0.84 | PDE4A (0.63) | MEN1KMT2AMAPTNPSR1GAA | |
| SCHEMBL7362724 | 0.82 | PDE4D (0.63) | MEN1KMT2ANPSR1LMNAALDH1A1 | |
| SCHEMBL7367868 | 0.82 | PDE4A (0.55) | MEN1KMT2AMAPTNPSR1GAA | |
| SCHEMBL7369609 | 0.82 | ALDH1A1 (0.46) | MEN1KMT2AMAPTNPSR1GAA | |
| SCHEMBL9379618 | 0.81 | PDE4A (0.56) | MEN1KMT2AMAPTGAALMNA | |
| SCHEMBL7359405 | 0.79 | PDE4A (0.61) | MEN1KMT2AMAPTNPSR1GAA | |
| SCHEMBL7365402 | 0.79 | PDE4A (0.73) | MEN1KMT2AMAPTNPSR1GAA | |
| SCHEMBL22721748 | 0.79 | MEN1 (0.68) | MEN1KMT2AMAPTNPSR1GAA | |
| SCHEMBL29539469 | 0.79 | MEN1 (0.68) | MEN1KMT2AMAPTNPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |