Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.61 |
| ▸ | F2 | P00734 | 10/20 | 0.61 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362951 | 0.81 | F2 (0.60) | MGLLF2PRSS1F10KCNH2 | |
| SCHEMBL7367913 | 0.76 | F2 (1.00) | MGLLF2PRSS1F10 | |
| SCHEMBL7363325 | 0.75 | F2 (0.58) | MGLLF2PRSS1F10KDM4E | |
| SCHEMBL7365097 | 0.73 | F2 (1.00) | F2PRSS1F10ACHE | |
| SCHEMBL7368689 | 0.73 | F2 (0.60) | F2PRSS1F10 | |
| SCHEMBL7362114 | 0.73 | F2 (0.69) | F2PRSS1F10 | |
| SCHEMBL7364521 | 0.72 | F2 (0.86) | F2PRSS1F10 | |
| SCHEMBL7362115 | 0.72 | F2 (0.82) | F2PRSS1F10ACHE | |
| SCHEMBL8158003 | 0.70 | GRIN2D (0.73) | F2 | |
| SCHEMBL7365961 | 0.70 | MEN1 (0.69) | F2PRSS1F10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0960102-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | Du Pont Pharmaceuticals Company (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998001428-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-01-15 | — | — | WO | disclosed |