Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 9/20 | 0.60 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365098 | 0.83 | F2 (0.61) | F2PRSS1GRIN2BTP53HSD17B10 | |
| SCHEMBL7365964 | 0.79 | TACR3 (0.63) | F2PRSS1GRIN2BTP53HSD17B10 | |
| SCHEMBL8158003 | 0.77 | GRIN2D (0.73) | F2GRIN2BGRIN1MEN1KMT2A | |
| SCHEMBL7367339 | 0.77 | GRIN2B (0.53) | HTR2BGRIN2BTP53HSD17B10GRIN1 | |
| SCHEMBL7407065 | 0.75 | F10 (0.56) | F2PRSS1F10 | |
| SCHEMBL7367913 | 0.75 | F2 (1.00) | F2PRSS1F10LMNA | |
| SCHEMBL5372866 | 0.75 | GAA (0.52) | F2GRIN2BGRIN1MEN1KMT2A | |
| SCHEMBL7365097 | 0.74 | F2 (1.00) | F2PRSS1F10 | |
| SCHEMBL7364712 | 0.74 | F2 (0.64) | F2PRSS1GRIN2BTP53HSD17B10 | |
| Hydrochloric Acid SCHEMBL7409025 | 0.74 | TPSAB1 (0.57) | F2PRSS1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0960102-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | Du Pont Pharmaceuticals Company (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998001428-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-01-15 | — | — | WO | disclosed |