SCHEMBL7370702

SCHEMBL7370702

COC(=O)C[C@H]1C(=O)N(CC(=O)O)CCN1C(=O)[C@@H](O)CC(=O)N1CCN(c2ccncc2)CC1

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 17/20 0.46
ITGA2B P08514 17/20 0.46
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
TSHR P16473 1/20 0.36
CASP1 P29466 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7935145 1.00 ITGB3 (0.46) ITGB3ITGA2BCYP3A4CYP2D6CYP2C9
SCHEMBL7370709 1.00 ITGB3 (0.46) ITGB3ITGA2BCYP3A4CYP2D6CYP2C9
SCHEMBL7444700 0.90 ITGB3 (0.45) ITGB3ITGA2BCYP3A4CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL7364672 0.89 ITGB3 (0.44) ITGB3ITGA2BCYP3A4CYP2D6CYP2C9
SCHEMBL7372928 0.89 ITGB3 (0.44) ITGB3ITGA2BCYP3A4CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL7370143 0.88 ITGB3 (0.43) ITGB3ITGA2BCYP3A4CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL7364908 0.88 ITGB3 (0.43) ITGB3ITGA2BCYP3A4CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL7363292 0.88 ITGB3 (0.43) ITGB3ITGA2BCYP3A4CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL7363302 0.88 ITGB3 (0.43) ITGB3ITGA2BCYP3A4CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL7363298 0.88 ITGB3 (0.43) ITGB3ITGA2BCYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6242600-B1 ANTIISCHEMIC AGENTS, ANTICOAGULANTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-06-05 US disclosed
EP-0970071-A1 2-PEPERAZINONE-1-ACETIC ACID DERIVATIVES AND THEIR USE Takeda Chemical Industries, Ltd. (JP) 2000-01-12 EP disclosed
WO-1998039324-A1 2-PEPERAZINONE-1-ACETIC ACID DERIVATIVES AND THEIR USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-09-11 WO disclosed