SCHEMBL7370869

SCHEMBL7370869

Cc1c(CO)nc2n1-c1ccc(Cl)cc1C(c1ccccc1F)=NC2

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OPRK1 P41145 5/20 0.62
CYP3A4 P08684 2/20 0.62
PDE4D Q08499 2/20 0.62
DRD3 P35462 2/20 0.62
SLC22A1 O15245 1/20 0.62
ABCB11 O95342 1/20 0.62
GABRA1 P14867 3/20 0.52
GABRA5 P31644 3/20 0.52
GABRA2 P47869 3/20 0.52
GABRA3 P34903 2/20 0.52
GABRG2 P18507 1/20 0.52
HTR2A P28223 1/20 0.52
GABRB3 P28472 1/20 0.52
ADRA1A P35348 1/20 0.52
HPGD P15428 2/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
PTAFR P25105 1/20 0.50
HTR1A P08908 1/20 0.50
HTR3A P46098 1/20 0.50
KCNH2 Q12809 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7950051 0.94 OPRK1 (0.56) OPRK1CYP3A4PDE4DDRD3SLC22A1
SCHEMBL8805527 0.94 OPRK1 (0.56) OPRK1CYP3A4PDE4DDRD3SLC22A1
SCHEMBL7377709 0.89 CYP3A4 (0.63) OPRK1CYP3A4PDE4DDRD3SLC22A1
SCHEMBL11827075 0.87 OPRK1 (0.67) OPRK1CYP3A4PDE4DDRD3SLC22A1
SCHEMBL7377708 0.85 CYP3A4 (0.57) OPRK1CYP3A4PDE4DDRD3SLC22A1
SCHEMBL7312348 0.85 OPRK1 (0.64) OPRK1CYP3A4PDE4DDRD3SLC22A1
SCHEMBL7373314 0.85 CYP3A4 (0.56) OPRK1CYP3A4PDE4DDRD3SLC22A1
Hydrochloric Acid SCHEMBL7376250 0.85 CYP3A4 (0.56) OPRK1CYP3A4PDE4DDRD3SLC22A1
SCHEMBL32673243 0.84 OPRK1 (0.60) OPRK1CYP3A4PDE4DDRD3SLC22A1
Hydrochloric Acid SCHEMBL7375440 0.84 CYP3A4 (0.55) OPRK1CYP3A4PDE4DDRD3SLC22A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0801651-B1 HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS HOFFMANN LA ROCHE (CH) 2001-07-11 EP disclosed
US-6174881-B1 USED AS ANXIOLYTIC AND/OR ANTICONVULSANT AND/OR MUSCLE RELAXANT AGENTS; SEDATIVES OR HYPNOSIS; WATER-SOLUBLE AMINE SALTS; FAST-ACTING HOFFMAN-LA ROCHE INC. 2001-01-16 US disclosed
EP-0801651-A1 HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS F. HOFFMANN-LA ROCHE AG (CH) 1997-10-22 EP disclosed
WO-1996020941-A1 HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS F. HOFFMANN-LA ROCHE AG (CH) 1996-07-11 WO disclosed