Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375486 | 0.80 | KDM4E (0.78) | KDM4EHTTCYP2A13TDP1CXCR4 | |
| SCHEMBL7372983 | 0.80 | KDM4E (1.00) | KDM4EHTTCYP2A13TDP1CXCR4 | |
| SCHEMBL7376116 | 0.79 | KDM4E (0.76) | KDM4EHTTCYP2A13TDP1CXCR4 | |
| SCHEMBL7373985 | 0.77 | DRD3 (0.58) | KDM4EHTT | |
| SCHEMBL7371482 | 0.75 | KDM4E (0.64) | KDM4EHTTCYP2A13TDP1ALDH1A1 | |
| SCHEMBL13850015 | 0.69 | CYP2A13 (1.00) | KDM4EHTTCYP2A13TDP1CXCR4 | |
| SCHEMBL3102589 | 0.69 | KDM4E (0.55) | KDM4EHTTCYP2A13CXCR4ALDH1A1 | |
| SCHEMBL1433979 | 0.68 | NPC1 (0.72) | HTTALDH1A1PKMPOLB | |
| SCHEMBL31193156 | 0.67 | KDM4E (0.60) | KDM4EHTTCYP2A13TDP1ALDH1A1 | |
| SCHEMBL18360700 | 0.67 | KDM4E (0.69) | KDM4EHTTCYP2A13TDP1CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243959-B1 | SUBSTITUTED BENZAMIDE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1992-08-19 | — | — | EP | disclosed |
| US-4870074-A | Substituted benzamide derivatives, for enhancing gastrointestinal motility | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1989-09-26 | — | — | US | disclosed |
| EP-0243959-A1 | Substituted benzamide derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same | Dainippon Pharmaceutical Co., Ltd. (JP) | 1987-11-04 | — | — | EP | disclosed |