Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.78 |
| ▸ | HTT | P42858 | 2/20 | 0.78 |
| ▸ | CYP2A13 | Q16696 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7372983 | 0.88 | KDM4E (1.00) | KDM4EHTTCYP2A13TDP1SIGMAR1 | |
| SCHEMBL7376116 | 0.88 | KDM4E (0.76) | KDM4EHTTCYP2A13TDP1SIGMAR1 | |
| SCHEMBL7370974 | 0.80 | KDM4E (0.64) | KDM4EHTTCYP2A13TDP1CXCR4 | |
| SCHEMBL7371482 | 0.80 | KDM4E (0.64) | KDM4EHTTCYP2A13TDP1ALDH1A1 | |
| SCHEMBL13850015 | 0.77 | CYP2A13 (1.00) | KDM4EHTTCYP2A13TDP1CXCR4 | |
| SCHEMBL18360700 | 0.74 | KDM4E (0.69) | KDM4EHTTCYP2A13TDP1SIGMAR1 | |
| SCHEMBL9161601 | 0.73 | KDM4E (0.67) | KDM4EHTTCYP2A13TDP1ALDH1A1 | |
| SCHEMBL9163382 | 0.73 | KDM4E (0.67) | KDM4EHTTCYP2A13TDP1ALDH1A1 | |
| SCHEMBL9390972 | 0.73 | KDM4E (0.67) | KDM4EHTTCYP2A13TDP1ALDH1A1 | |
| SCHEMBL31024625 | 0.71 | KDM4E (0.51) | KDM4EHTTCYP2A13SIGMAR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243959-B1 | SUBSTITUTED BENZAMIDE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1992-08-19 | — | — | EP | disclosed |
| US-4870074-A | Substituted benzamide derivatives, for enhancing gastrointestinal motility | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1989-09-26 | — | — | US | disclosed |
| EP-0243959-A1 | Substituted benzamide derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same | Dainippon Pharmaceutical Co., Ltd. (JP) | 1987-11-04 | — | — | EP | disclosed |