Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | ADH1A | P07327 | 3/20 | 0.41 |
| ▸ | ADH1C | P00326 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11296512 | 1.00 | HRH3 (0.45) | HRH3HRH4ADH1AADH1CKDM4E | |
| SCHEMBL737029 | 0.97 | — | — | |
| SCHEMBL2099469 | 0.95 | — | — | |
| SCHEMBL1451963 | 0.86 | — | — | |
| SCHEMBL736403 | 0.80 | HRH3 (0.42) | HRH3HRH4ADH1AADH1CKDM4E | |
| SCHEMBL11292771 | 0.80 | HRH3 (0.42) | HRH3HRH4ADH1AADH1CKDM4E | |
| SCHEMBL7691331 | 0.78 | HRH3 (0.48) | HRH3HRH4ADH1AADH1CKDM4E | |
| SCHEMBL735581 | 0.77 | HRH3 (0.39) | HRH3HRH4ADH1AADH1CKDM4E | |
| SCHEMBL2104188 | 0.77 | PIK3CD (0.30) | — | |
| SCHEMBL735849 | 0.77 | HRH3 (0.40) | HRH3HRH4ADH1AADH1CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020198376-A1 | Novel urea derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-12-26 | — | — | US | claimed |
| US-6492370-B1 | Urea derivatives and pharmaceutical compositions thereof | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-12-10 | — | — | US | claimed |
| WO-2002012166-A2 | TRIAMINE DERIVATIVE MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | LION BIOSCIENCE AG (DE) | 2002-02-14 | — | — | WO | claimed |
| EP-1072591-A1 | NOVEL UREA DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-01-31 | — | — | EP | claimed |
| US-4656256-A | Benzoazoresorcinol dyes containing a quaternized aminoalkylene oxycarbonyl group | BASF AKTIENGESELLSCHAFT (DE) | 1987-04-07 | — | — | US | claimed |
| EP-3750894-B1 | UREA-SUBSTITUTED AROMATIC RING-LINKED DIOXAZOLINE COMPOUND, PREPARATION METHOD THEREFOR, AND USES THEREOF | BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) | 2024-04-03 | — | — | EP | disclosed |
| CN-116802184-A | Pyrazolothiazole carboxamides and their use as PDGFR inhibitors | 埃科特莱茵药品有限公司 | 2023-09-22 | — | — | CN | disclosed |
| EP-3750893-B1 | DIOXAZOLINE COMPOUND, PREPARATION METHOD THEREFOR, AND USES THEREOF | BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) | 2023-04-19 | — | — | EP | disclosed |
| CN-111788207-B | Dioxane quinoline compound and preparation method and application thereof | 北京赛特明强医药科技有限公司 | 2021-03-23 | — | — | CN | disclosed |
| CN-111757885-B | Urea-substituted aromatic ring-connected dioxane quinoline compound and preparation method and application thereof | 北京赛特明强医药科技有限公司 | 2021-01-29 | — | — | CN | disclosed |
| CN-110156804-B | Dioxane quinoline compound and preparation method thereof | 北京赛特明强医药科技有限公司 | 2021-01-12 | — | — | CN | disclosed |
| US-20200399284-A1 | UREA-SUBSTITUTED AROMATIC RING-LINKED DIOXINOQUINOLINE COMPOUNDS, PREPARATION METHOD AND USES THEREOF | BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) | 2020-12-24 | — | — | US | disclosed |
| EP-0159549-B1 | BASIC AZO DYES | BASF Aktiengesellschaft (DE) | 1987-07-08 | — | — | EP | disclosed |
| US-4656256-A | Benzoazoresorcinol dyes containing a quaternized aminoalkylene oxycarbonyl group | BASF AKTIENGESELLSCHAFT (DE) | 1987-04-07 | — | — | US | disclosed |
| US-4652632-A | Naphtholazo benzoylalkylene amines and salts thereof as dyes for acid-modified fibers, leather and paper | BASF AKTIENGESELLSCHAFT (DE) | 1987-03-24 | — | — | US | disclosed |
| EP-0189836-A1 | Basic azo dyes | BASF Aktiengesellschaft (DE) | 1986-08-06 | — | — | EP | disclosed |
| EP-0162409-A2 | Basic azo dyes | BASF Aktiengesellschaft (DE) | 1985-11-27 | — | — | EP | disclosed |
| EP-0159549-A1 | Basic azo dyes | BASF Aktiengesellschaft (DE) | 1985-10-30 | — | — | EP | disclosed |
| EP-0061623-A1 | Process for dyeing or printing paper, and cationic phthalocyanine dyes | BASF Aktiengesellschaft (DE) | 1982-10-06 | — | — | EP | disclosed |
| EP-0061624-A1 | Cationic dyes and their use | BASF Aktiengesellschaft (DE) | 1982-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200399284-A1 | UREA-SUBSTITUTED AROMATIC RING-LINKED DIOXINOQUINOLINE COMPOUNDS, PREPARATION METHOD AND USES THEREOF | RET, BRAF, RAF1 | HRH3 1094/4885HRH4 1206/4885ADH1A 1089/4885 |
| US-20020198376-A1 | Novel urea derivatives | TNF, CTH, CFH | HRH3 19/4885HRH4 4/4885ADH1A 1471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.