Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 20/20 | 1.00 |
| ▸ | EDNRB | P24530 | 15/20 | 1.00 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.76 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.76 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.76 |
| ▸ | PDE4A | P27815 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4631377 | 1.00 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL4630589 | 0.93 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL4631360 | 0.91 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL4632386 | 0.89 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL14044059 | 0.89 | EDNRA (0.80) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL7961933 | 0.89 | EDNRA (0.81) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL4631411 | 0.89 | EDNRA (0.81) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| Sitaxentan SCHEMBL29372653 | 0.86 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| Sitaxentan SCHEMBL803344 | 0.86 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| Sitaxentan SCHEMBL4142779 | 0.86 | EDNRA (0.98) | EDNRAEDNRBABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819125-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031492-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1996-10-10 | — | — | WO | disclosed |