Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 2/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7372848 | 1.00 | ACE (0.43) | ACECYP3A4TSHRTDP1MAPT | |
| SCHEMBL10332106 | 1.00 | ACE (0.43) | ACECYP3A4TSHRTDP1MAPT | |
| SCHEMBL10331868 | 1.00 | ACE (0.43) | ACECYP3A4TSHRTDP1MAPT | |
| SCHEMBL9609014 | 0.95 | ACE (0.40) | ACECYP3A4TSHRTDP1MAPT | |
| SCHEMBL10331862 | 0.95 | ACE (0.40) | ACECYP3A4TSHRTDP1MAPT | |
| SCHEMBL26256186 | 0.95 | ACE (0.40) | ACECYP3A4TSHRTDP1MAPT | |
| SCHEMBL12034318 | 0.95 | ACE (0.40) | ACECYP3A4TSHRTDP1MAPT | |
| SCHEMBL8358700 | 0.92 | XIAP (0.38) | ACECYP3A4TSHRTDP1MAPT | |
| SCHEMBL5832039 | 0.92 | XIAP (0.38) | ACECYP3A4TSHRTDP1MAPT | |
| SCHEMBL5832021 | 0.92 | XIAP (0.38) | ACECYP3A4TSHRTDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654294-A | CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB (US) | 1997-08-05 | — | — | US | disclosed |
| EP-0783002-A2 | Dual action inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-07-09 | — | — | EP | disclosed |
| US-5646276-A | ANGIOTENSIN CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE INHIBITORS; CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5552397-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-09-03 | — | — | US | disclosed |
| EP-0599444-A1 | Dual action inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1994-06-01 | — | — | EP | disclosed |